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MY-9B

Chemical Structure : MY-9B

CAS No.: 3020765-60-7

MY-9B (SARM1 inhibitor)

Catalog No.: PC-49271Not For Human Use, Lab Use Only.

MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1.

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    Biological Activity

    MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1.
    MY-9B inhibits the NADase activity of WT-SARM1, but not C311A or C311S SARM1 mutants, show a high degree of proteome-wide selectivity for SARM1 C311.
    MY-9B (10-20 uM) stereoselectively blocks vincristine- and vacor-induced neurite degeneration in primary rodent dorsal root ganglion neurons.

    Physicochemical Properties

    M.Wt 403.438
    Formula C23H21N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (1R,3R)-2-acryloyl-1-(benzo[d][1,3]dioxol-5-yl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide

    References

    1. Hannah C Feldman, et al. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2208457119.

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