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Elamipretide

Chemical Structure : Elamipretide

CAS No.: 736992-21-5

Elamipretide (SS-31, MTP-131, Bendavia)

Catalog No.: PC-61855Not For Human Use, Lab Use Only.

Elamipretide (SS-31, MTP-131, Bendavia) is a novel cell-permeable antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that targets inner mitochondrial membrane and prevents oxidative damage of neuronal cells and other cell type.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Elamipretide (SS-31, MTP-131, Bendavia) is a novel cell-permeable antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that targets inner mitochondrial membrane and prevents oxidative damage of neuronal cells and other cell types.
Elamipretide prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.

Physicochemical Properties

M.Wt 639.802
Formula C32H49N9O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-6-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide

References

1. Thomas DA, et al. J Am Soc Nephrol. 2007 Jan;18(1):213-22.

2. Zhao K, et al. Biochem Pharmacol. 2005 Dec 5;70(12):1796-806.

3. Mizuguchi Y, et al. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1545-53.

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