Catalog No.: PC-62928Not For Human Use, Lab Use Only.
Buthionine Sulfoximine (BSO) is a glutathione (GSH)-depleting reagent that inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis.
Buthionine Sulfoximine (BSO) is a glutathione (GSH)-depleting reagent that inhibits gamma-glutamylcysteine synthetase (GCS, also referred to as glutamate-cysteine ligase, GLCL), the enzyme required in the first step of glutathione synthesis.
Buthionine Sulfoximine synergistically enhances melphalan activity against preclinical models of multiple myeloma.
Physicochemical Properties
M.Wt
222.305
Formula
C8H18N2O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-amino-4-(S-butylsulfonimidoyl)-butanoic acid
References
1. Habermann KJ, et al. Cell Death Dis. 2017 Oct 5;8(10):e3067.
2. Yang WS, et al. Cell. 2014 Jan 16;156(1-2):317-331.
3. Tagde A, et al. Blood Cancer J. 2014 Jul 18;4:e229.
