Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Buthionine Sulfoximine
CAS No.: 5072-26-4
Catalog No.: PC-62928Not For Human Use, Lab Use Only.
Buthionine Sulfoximine (BSO) is a glutathione (GSH)-depleting reagent that inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $58 | In stock | |
| 100 mg | $88 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Buthionine Sulfoximine (BSO) is a glutathione (GSH)-depleting reagent that inhibits gamma-glutamylcysteine synthetase (GCS, also referred to as glutamate-cysteine ligase, GLCL), the enzyme required in the first step of glutathione synthesis.
Buthionine Sulfoximine synergistically enhances melphalan activity against preclinical models of multiple myeloma.
| M.Wt | 222.305 | |
| Formula | C8H18N2O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-amino-4-(S-butylsulfonimidoyl)-butanoic acid |
|
1. Habermann KJ, et al. Cell Death Dis. 2017 Oct 5;8(10):e3067.
2. Yang WS, et al. Cell. 2014 Jan 16;156(1-2):317-331.
3. Tagde A, et al. Blood Cancer J. 2014 Jul 18;4:e229.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
