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CKi-4

Chemical Structure : CKi-4

CAS No.: 2768295-28-7

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CKi-4 (Creatine kinase inhibitor CKi-4)

Catalog No.: PC-20158Not For Human Use, Lab Use Only.

Creatine kinase inhibitor CKi-4 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 0.3 uM, depletes creatine phosphagen energetics in cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Creatine kinase inhibitor CKi-4 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 0.3 uM, depletes creatine phosphagen energetics in cells.
    CKi-4 selectively engages the active site cysteine (Cys283) of CKs in cells.
    CKi-4 inhibits cell viability in UCSD-AML1 cells with EC50 of 1.8 uM.

    Physicochemical Properties

    M.Wt 333.57
    Formula C11H10BrClN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-bromo-4-(2-chloroacetyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

    References

    1. Narek Darabedian, et al. Nat Chem Biol. 2023 Feb 23. doi: 10.1038/s41589-023-01273-x.

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