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MIF2 inhibitor 5d

Chemical Structure : MIF2 inhibitor 5d

CAS No.: 2917525-79-0

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MIF2 inhibitor 5d

Catalog No.: PC-20214Not For Human Use, Lab Use Only.

MIF2 inhibitor 5d is a selective inhibitor of d-dopachrome tautomerase (d-DT or MIF2) with IC50 of 1.0 μM for MIF2 tautomerase activity and a high selectivity over MIF.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MIF2 inhibitor 5d is a selective inhibitor of d-dopachrome tautomerase (d-DT or MIF2) with IC50 of 1.0 μM for MIF2 tautomerase activity and a high selectivity over MIF.
    MIF2 inhibitor 5d suppresses the proliferation of non-small cell lung cancer cells in two-dimensional (2D) and three-dimensional (3D) cell cultures, by the induction of cell cycle arrest via deactivation of the mitogen-activated protein kinase (MAPK) pathway

    Physicochemical Properties

    M.Wt 480.51
    Formula C26H19F3N2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-5-methyl-3-(1-(naphthalen-1-yl)ethyl)-6-(3-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

    References

    1. Zhangping Xiao, et al. J Med Chem. 2022 Feb 10;65(3):2059-2077.

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