MIF2 inhibitor 5d

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Chemical Structure : MIF2 inhibitor 5d

Catalog No.: PC-20214Not For Human Use, Lab Use Only.

MIF2 inhibitor 5d is a selective inhibitor of d-dopachrome tautomerase (d-DT or MIF2) with IC50 of 1.0 μM for MIF2 tautomerase activity and a high selectivity over MIF.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MIF2 inhibitor 5d is a selective inhibitor of d-dopachrome tautomerase (d-DT or MIF2) with IC50 of 1.0 μM for MIF2 tautomerase activity and a high selectivity over MIF.
MIF2 inhibitor 5d suppresses the proliferation of non-small cell lung cancer cells in two-dimensional (2D) and three-dimensional (3D) cell cultures, by the induction of cell cycle arrest via deactivation of the mitogen-activated protein kinase (MAPK) pathway

Physicochemical Properties

M.Wt	480.51
Formula	C26H19F3N2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-methyl-3-(1-(naphthalen-1-yl)ethyl)-6-(3-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

References

1. Zhangping Xiao, et al. J Med Chem. 2022 Feb 10;65(3):2059-2077.

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