PKN3 inhibitor 16 is a potent, cell active protein kinase novel 3 (PKN3) inhibitor with biochemical IC50 of 14 nM, celluar IC50 of 1.3 uM.
PKN3 presents a useful potential tool compound to study the biology of PKN3 including links to pancreatic and prostate cancer, along with T-cell acute lymphoblastic leukemia.
Protein kinase N (PKN, protein kinase novel) family genes encode for the three isoforms PKN1 (PKNα/PRK1/PAK1), PKN2 (PKNγ/PRK2/PAK2/) and PKN3 (PKNβ) that form the subfamily of AGC serine/threonine protein kinases.
