PKN3 inhibitor 16

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Chemical Structure : PKN3 inhibitor 16

Catalog No.: PC-38564Not For Human Use, Lab Use Only.

PKN3 inhibitor 16 is a potent, cell active protein kinase novel 3 (PKN3) inhibitor with biochemical IC50 of 14 nM, celluar IC50 of 1.3 uM.

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Biological Activity

PKN3 inhibitor 16 is a potent, cell active protein kinase novel 3 (PKN3) inhibitor with biochemical IC50 of 14 nM, celluar IC50 of 1.3 uM.
PKN3 presents a useful potential tool compound to study the biology of PKN3 including links to pancreatic and prostate cancer, along with T-cell acute lymphoblastic leukemia.
Protein kinase N (PKN, protein kinase novel) family genes encode for the three isoforms PKN1 (PKNα/PRK1/PAK1), PKN2 (PKNγ/PRK2/PAK2/) and PKN3 (PKNβ) that form the subfamily of AGC serine/threonine protein kinases.

Physicochemical Properties

M.Wt	436.249
Formula	C18H17IN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-iodo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine

References

1. Asquith CRM, et al. ChemMedChem. 2022 Apr 11.

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