Chemical Structure : Ibetazol
CAS No.:
Ibetazol
(CDD-03, Inhibitor of importin beta)
Catalog No.: PC-23494Not For Human Use, Lab Use Only.
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1.
Ibetazol interacts with cysteine 585 in importin β1, and thereby effectively prohibits both direct and adaptor (importin α) protein-dependent importin β1-mediated nuclear import.
Ibetazol has EC50 of 6.3 uM in phenotypic importin α1 translocation assays, with no cytotoxicity in HEK293T cells.
Ibetazol specifically inhibit importin β1-dependent import (the direct importin β1 dependent cargo SREBP1, importin α1, and importin β1-importin α cargos).
Physicochemical Properties
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M.Wt
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300.30
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Formula
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C13H11F3N2OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(ethylsulfinyl)-4-phenyl-6-(trifluoromethyl)pyrimidine
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References
1. Vercruysse T, et al. Commun Biol. 2024 Nov 23;7(1):1560.
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