Chemical Structure : Ibetazol
CAS No.:
Ibetazol
(CDD-03, Inhibitor of importin beta)
Catalog No.: PC-23494Not For Human Use, Lab Use Only.
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1.
Ibetazol interacts with cysteine 585 in importin β1, and thereby effectively prohibits both direct and adaptor (importin α) protein-dependent importin β1-mediated nuclear import.
Ibetazol has EC50 of 6.3 uM in phenotypic importin α1 translocation assays, with no cytotoxicity in HEK293T cells.
Ibetazol specifically inhibit importin β1-dependent import (the direct importin β1 dependent cargo SREBP1, importin α1, and importin β1-importin α cargos).
Physicochemical Properties
|
M.Wt
|
300.30
|
|
Formula
|
C13H11F3N2OS
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-(ethylsulfinyl)-4-phenyl-6-(trifluoromethyl)pyrimidine
|
References
1. Vercruysse T, et al. Commun Biol. 2024 Nov 23;7(1):1560.
Contact Us
sales@probechem.com
