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SLCB050

Chemical Structure : SLCB050

CAS No.: 1848971-16-3

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SLCB050 (SLC-B050)

Catalog No.: PC-23229Not For Human Use, Lab Use Only.

SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression.
SLCB050 also blocks the interaction of DX2 and AIMP2, but not on p53-AIMP2 or DX2 binding and p14/ARF.
SLCB050 reduced the viability of human lung cancer cells, especially small cell lung cancer cells, in a p14/ARF-dependent manner.
SLCB050 inhibits tumor progression in mouse model of K-Ras-driven lung tumorigenesis, ectopic expression of DX2 induced small cell and non–small cell lung cancers.

Physicochemical Properties

M.Wt 366.37
Formula C21H18O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl (E)-3-(furan-2-yl)acrylate

References

1. Oh AY, et al. Cancer Res. 2016 Aug 15;76(16):4791-804.

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