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Chemical Structure : SLCB050
Catalog No.: PC-23229Not For Human Use, Lab Use Only.
SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression.
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SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression.
SLCB050 also blocks the interaction of DX2 and AIMP2, but not on p53-AIMP2 or DX2 binding and p14/ARF.
SLCB050 reduced the viability of human lung cancer cells, especially small cell lung cancer cells, in a p14/ARF-dependent manner.
SLCB050 inhibits tumor progression in mouse model of K-Ras-driven lung tumorigenesis, ectopic expression of DX2 induced small cell and non–small cell lung cancers.
| M.Wt | 366.37 | |
| Formula | C21H18O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Oh AY, et al. Cancer Res. 2016 Aug 15;76(16):4791-804.
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