Catalog No.: PC-35343Not For Human Use, Lab Use Only.
PFKFB4 inhibitor 5MPN is a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3.
PFKFB4 inhibitor 5MPN is a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3.
PFKFB4 inhibitor 5MPN suppresses the glycolysis and proliferation of multiple human cancer cell lines but not non-transformed epithelial cells in vitro.
PFKFB4 inhibitor 5MPN suppresses the glucose metabolism and growth of tumors in mice.
Physicochemical Properties
M.Wt
305.334
Formula
C15H19N3O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-(n-(8-methoxy-4-quinolyl)amino)pentyl nitrate
References
1. Chesney J, et al. Oncotarget. 2015 Jul 20;6(20):18001-11.
