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5MPN

Chemical Structure : 5MPN

CAS No.: 47208-82-2

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5MPN (PFKFB4 inhibitor 5MPN)

Catalog No.: PC-35343Not For Human Use, Lab Use Only.

PFKFB4 inhibitor 5MPN is a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3.

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5 mg $188 In stock
10 mg $298 In stock
25 mg $478 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PFKFB4 inhibitor 5MPN is a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3.
PFKFB4 inhibitor 5MPN suppresses the glycolysis and proliferation of multiple human cancer cell lines but not non-transformed epithelial cells in vitro.
PFKFB4 inhibitor 5MPN suppresses the glucose metabolism and growth of tumors in mice.

Physicochemical Properties

M.Wt 305.334
Formula C15H19N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(n-(8-methoxy-4-quinolyl)amino)pentyl nitrate

References

1. Chesney J, et al. Oncotarget. 2015 Jul 20;6(20):18001-11.

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