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GAK inhibitor 12r

Chemical Structure : GAK inhibitor 12r

CAS No.: 2241325-66-4

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GAK inhibitor 12r

Catalog No.: PC-35411Not For Human Use, Lab Use Only.

GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM.
    GAK inhibitor 12r targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases.
    GAK inhibitor 12r demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses.

    Physicochemical Properties

    M.Wt 370.471
    Formula C19H22N4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-(cis-2,6-Dimethylmorpholino)isothiazolo[4,3-b]pyridin-6-yl)-2-methoxyaniline

    References

    1. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613.

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