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FPD5

Chemical Structure : FPD5

CAS No.: 1346653-06-2

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FPD5

Catalog No.: PC-23540Not For Human Use, Lab Use Only.

FPD5 is a small molecule activator of esterase D (ESD) with KD value of 0.8 nM, directly binds to ESD at Lys180 rather than its ubiquitination site Lys213.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FPD5 is a small molecule activator of esterase D (ESD) with KD value of 0.8 nM, directly binds to ESD at Lys180 rather than its ubiquitination site Lys213.
FPD5 increases ESD activity with FPD5 at 0.1 μM and 1 μM for 24 h in L-02 cells.
FPD5 promotes ESD mono-ubiquitination in HEK293T cells.
Mutations K180A and K213A inhibited the interaction of FPD5 and ESD.
FPD5 inhibits cancer cell growth by arresting the cell cycle of A549 cells via the JAB1/p53 signaling pathway.

Physicochemical Properties

M.Wt 349.82
Formula C20H16ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-chloro-2-(5-phenyl-1-(pyridin-2-yl)-4, 5-dihydro-1H-pyrazol-3-yl) phenol

References

1. Chen X, et al. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127150.

2. Yao W, et al. Genes (Basel). 2022 Apr 28;13(5):786.

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