LH1513 | CaOx crystallization inhibitor

Chemical Structure : LH1513

LH1513 (L-Lysine Dioxalate)

Catalog No.: PC-23544Not For Human Use, Lab Use Only.

LH1513 (L-Lysine Dioxalate) is potent inhibitor of calcium oxalate (CaOx) crystallization with EC50 of 21.7 uM.

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Biological Activity

LH1513 (L-Lysine Dioxalate) is potent inhibitor of calcium oxalate (CaOx) crystallization with EC50 of 21.7 uM.
LH1513 (L-Lysine Dioxalate) is more potent than citrate and pyruvate.
LH1513 (L-Lysine Dioxalate) ahs sufficient oral bioavailability for a preliminary in vivo study demonstrating efficacy in preventing urinary CaOx crystal formation in an Agxt-knockout mouse model for hyperoxaluria.

Physicochemical Properties

M.Wt	356.17
Formula	C10H11N2Na3O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (S)-2,2'-((1-carboxylatopentane-1,5-diyl)bis(azanediyl))bis(2-oxoacetate)

References

1. Longqin Hu, et al. ACS Med Chem Lett. 2024 Nov 4;15(11):2005-2011.

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LH1513 (L-Lysine Dioxalate)

Biological Activity

Physicochemical Properties

References

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