Catalog No.: PC-23021Not For Human Use, Lab Use Only.
SRSF10 inhibitor 1C8 is a specific small molecule inhibitor of SRSF1, alters splicing regulation mediated by SRSF10, shows strong anti-HIV-1 potency against a variety of clinical strains in vitro.
SRSF10 inhibitor 1C8 is a specific small molecule inhibitor of SRSF1, alters splicing regulation mediated by SRSF10, shows strong anti-HIV-1 potency against a variety of clinical strains in vitro. SRSF10 inhibitor 1C8 decreases expression of Tat, Gag and Env, similar with RNA interference. SRSF10 inhibitor 1C8 selectively promotes the dephosphorylation of SRSF10 and increases its interaction with hTra2β, a protein previously implicated in the control of HIV-1 RNA splicing. SRSF10 inhibitor 1C8 inhibited the expression of HCC tumor in vivo.
