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SBL-105

Chemical Structure : SBL-105

CAS No.:

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SBL-105 (SBL105)

Catalog No.: PC-20062Not For Human Use, Lab Use Only.

SBL-105 (SBL105) is a potent, selective DHODH inhibitor with IC50 of 48.48 nM (rh DHODH).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SBL-105 (SBL105) is a potent, selective DHODH inhibitor with IC50 of 48.48 nM (rh DHODH).
    SBL-105 shows high binding efficacy toward DHODH with a ΔGbinding score of -10.9 kcal/mol.
    SBL-105 inhibits the proliferations of THP-1 cell with a GI50 value of 60.66 nM, and TF-1 cells with GI50 value of 45.33 nM, and HL-60 and SKM-1 cells are 73.98 and 86.01 nM, respectively
    SBL-105 increases S-phase cell cycle arrest and total apoptosis, also increases the differentiation marker CD11b-positive populations in both THP-1 and TF-1 cells.

    Physicochemical Properties

    M.Wt 300.36
    Formula C21H16O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-3-(4-methylbenzylidene)-2,3-dihydro-4H-benzo[g]chromen-4-one

    References

    1. Kamli H, et al. Oncol Res. 2022 Jan 31;28(9):899-911.

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