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Chemical Structure : UNC7467
CAS No.: 2922283-43-8
Catalog No.: PC-38497Not For Human Use, Lab Use Only.
UNC7467 is a potent, selective inositol hexakisphosphate kinase (IP6K) inhibitor with IC50 values of 8.9 nM (IP6K1), 4.9 nM (IP6K2) and 1320 nM (IP6K3).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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UNC7467 is a potent, selective inositol hexakisphosphate kinase (IP6K) inhibitor with IC50 values of 8.9 nM (IP6K1), 4.9 nM (IP6K2) and 1320 nM (IP6K3).
UNC7467 reduced levels of inositol pyrophosphates by 66-81% in HCT116 colon cancer cell line, without significantly perturbing levels of other inositol phosphates.
UNC7467 improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake in diet-induced obese (DIO) mice.
UNC7467 is an in vivo chemical probe for IP6K-related research.
| M.Wt | 315.328 | |
| Formula | C20H13NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-([1,1'-biphenyl]-4-yl)benzo[c]isoxazole-6-carboxylic acid |
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1. Yubai Zhou, et al. J Med Chem. 2022. DOI: 10.1021/acs.jmedchem.2c00220
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