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Retro 1

Chemical Structure : Retro 1

CAS No.: 313683-81-7

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Retro 1 (Retro-1)

Catalog No.: PC-62657Not For Human Use, Lab Use Only.

Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.
    Retro 1 has no effect on endogenous retrograde cargo proteins; protects mice against ricin challenge.

    Physicochemical Properties

    M.Wt 373.25
    Formula C18H17BrN2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

    References

    1. Stechmann B, et al. Cell. 2010 Apr 16;141(2):231-42.

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