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Chemical Structure : Brequinar
CAS No.: 96187-53-0
Catalog No.: PC-62689Not For Human Use, Lab Use Only.
Brequinar (DuP785, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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Brequinar (DuP785, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM.
Brequinar arrests tumor growth in HL60 and MOLM13 subcutaneous xenograft models of AML in NOD SCID mice.
| M.Wt | 375.37 | |
| Formula | C23H15F2NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid |
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1. Sykes DB, et al. Cell. 2016 Sep 22;167(1):171-186.e15.
2. Dexter DL, et al. Cancer Res. 1985 Nov;45(11 Pt 1):5563-8.
3. Chen SF, et al. Cancer Res. 1986 Oct;46(10):5014-9.
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