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Brequinar

Chemical Structure : Brequinar

CAS No.: 96187-53-0

Brequinar (DuP785, NSC 368390, FTo inhibitor CS2)

Catalog No.: PC-62689Not For Human Use, Lab Use Only.

Brequinar (DuP785, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Brequinar (DuP785, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM.
Brequinar (CS2) is a highly efficacious FTO inhibitor with potent anti-leukemic efficacy.
Brequinar arrests tumor growth in HL60 and MOLM13 subcutaneous xenograft models of AML in NOD SCID mice.

Physicochemical Properties

M.Wt 375.37
Formula C23H15F2NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

References

1. Sykes DB, et al. Cell. 2016 Sep 22;167(1):171-186.e15.

2. Dexter DL, et al. Cancer Res. 1985 Nov;45(11 Pt 1):5563-8.

3. Chen SF, et al. Cancer Res. 1986 Oct;46(10):5014-9.

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