Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MEISi-1
CAS No.: 446306-43-0
Catalog No.: PC-20504Not For Human Use, Lab Use Only.
MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity.
MEISi-1 (0.1-10 uM) induced MEIS dependent hematopoietic stem cell maintenance and self-renewal.
MEISi-1 downregulated MEIS target gene expression (Hif-1α, Hif-2α, and HSC quiescence modulators Foxo3, Nfat5, and Ptpmt1).
MEISi-1 functionally inhibited MEIS in vivo, induces c-Kit+ cell, Sca1+ cell, CD150+cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48-HSC content.
MEISi-1 was effective in vivo as evident by induced HSC content in the murine bone marrow and downregulation of expression of MEIS target genes.
| M.Wt | 388.47 | |
| Formula | C24H24N2O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
O=C(NC1=CC=CC(C)=C1C)C2=CC=C(OCC(NCC3=CC=CC=C3)=O)C=C2 |
|
1. Raife Dilek Turan, et al. Sci Rep. 2020 May 14;10(1):7994.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
