Catalog No.: PC-20504Not For Human Use, Lab Use Only.
MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity.
MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity.
MEISi-1 (0.1-10 uM) induced MEIS dependent hematopoietic stem cell maintenance and self-renewal.
MEISi-1 downregulated MEIS target gene expression (Hif-1α, Hif-2α, and HSC quiescence modulators Foxo3, Nfat5, and Ptpmt1).
MEISi-1 functionally inhibited MEIS in vivo, induces c-Kit+ cell, Sca1+ cell, CD150+cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48-HSC content.
MEISi-1 was effective in vivo as evident by induced HSC content in the murine bone marrow and downregulation of expression of MEIS target genes.
