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Auranofin

Chemical Structure : Auranofin

CAS No.: 34031-32-8

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Auranofin (SKF-39162, SKF39162)

Catalog No.: PC-20604Not For Human Use, Lab Use Only.

Auranofin (SKF39162) is a specific inhibitor of thioredoxin reductase (TrxR), also is a potent UBA1 E1 ubiquitin-activating enzyme activity enhancer.

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10 mg $78 In stock
25 mg $138 In stock
50 mg $228 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Auranofin is a specific inhibitor of thioredoxin reductase (TrxR), also is a potent UBA1 E1 ubiquitin-activating enzyme activity enhancer.
Auranofin efficiently inhibits both full-length TrxR1 and TrxR2 and truncated TrxR2.
Auranofin binds to the UBA1's ubiquitin fold domain and conjugates to Cys1039 residue.
Auranofin enhances UBA1 interactions with at least 20 different E2 ubiquitin-conjugating enzymes, facilitating ubiquitin charging to E2 and increasing the activities of seven representative E3s in vitro.
Auranofin promotes ubiquitination and degradation of misfolded ER proteins during ER-associated degradation in cells at low nanomolar concentrations.

Physicochemical Properties

M.Wt 678.49
Formula C20H34AuO9PS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((2S,3R,4S,5R,6R)-3,4,5-Triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-thio)(triethylphosphine)gold

References

1. Cañas A, et al. Breast Cancer Res. 2012 Dec 5;14(6):R153.
2. Dai B, et al. Cancer Res. 2013 Sep 1;73(17):5532-43.
3. Yan W, et al. Nat Commun. 2023 Aug 9;14(1):4798.

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