YQ456 (YQ-456) is a specific small molecule inhibitor of Myoferlin (MYOF) with high binding affinity (KD=37 nM) to MYOF‐C2D domain, suppresses colorectal cancer invasion in vitro with IC50 of 110 nM.
YQ456 has 36 times higher binding affinity than that of WJ460 (Cat. PC-35673), also shows high binding affinity MYOF‐C2D domain with Kd of 214 nM in biolayer interferometry (BLI) assays.
YQ456 displays no binding affinity between YQ456 and DYSF‐C2D domain.
YQ456 exhibits anti‐proliferative effect in colorectal cancer cells (HCT116 cells and LoVo cells) in vitro.
YQ456 (25, 50 mg/kg) prevents colorectal cancer growth in a subcutaneous xenograft mouse model, shows a higher inhibitory effect on tumor growth than regorafenib (Cat. PC-42530) at the same concentration.
YQ456 suppresses the liver metastasis of colorectal cancer, hinders colorectal cancer development in a PDX xenograft mouse model.