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IPHBA

Chemical Structure : IPHBA

CAS No.: 325777-00-2

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IPHBA

Catalog No.: PC-47049Not For Human Use, Lab Use Only.

IPHBA is a small-molecule inhibitor that suppresses EPAS1-driven IL-31 induction, selectively inhibits TCR-mediated IL-31 induction in murine CD4+ T cells with IC50 of 10.6 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IPHBA is a small-molecule inhibitor that suppresses EPAS1-driven IL-31 induction, selectively inhibits TCR-mediated IL-31 induction in murine CD4+ T cells with IC50 of 10.6 uM.
    IPHBA inhibits the association between EPAS1 and SP1, and impairs recruitment of both transcription factors to the specific sites of the IL31 promoter.
    IPHBA inhibits IL-31 induction in murine and human TH cells without affecting other cytokine production and hypoxic responses.

    Physicochemical Properties

    M.Wt 282.343
    Formula C17H18N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-(4-isopropylbenzylidene)hydrazineyl)benzoic acid

    References

    1. Yasuhisa Kamikaseda, et al. J Allergy Clin Immunol. 2021 Aug;148(2):633-638.

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