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GNF-9228

Chemical Structure : GNF-9228

CAS No.: 313234-20-7

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GNF-9228 (GNF9228)

Catalog No.: PC-47060Not For Human Use, Lab Use Only.

GNF-9228 is a small molecule that stimulates human β-cell proliferation, selectively activates human β-cell relative to α- or δ-cell proliferation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GNF-9228 is a small molecule that stimulates human β-cell proliferation, selectively activates human β-cell relative to α- or δ-cell proliferation.
    GNF-9228 stimulates insulin secretion in rat and human islets.
    GNF-9228 protects 832/13 cells from ER stress and cytokine-induced cytotoxicity.
    Rat islet cell proliferation induced by GNF-9228 is not inhibited by overexpression of DYRK1A.

    Physicochemical Properties

    M.Wt 294.310
    Formula C17H14N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-Hydroxy-2-[(4-methylphenyl)imino]-2H-1-benzopyran-3-carboxamide

    References

    1. Hans E Hohmeier, et al. PLoS One. 2020 Mar 16;15(3):e0224344.

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