Chemical Structure : CDNB
CAS No.:
97-00-7
CDNB
Catalog No.: PC-23929Not For Human Use, Lab Use Only.
CDNB is a selective small molecule inhibitor of thioredoxin reductase (TrxR), inhibits TrxR activity with IC50 of 9.4 uM in raw macrophages.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDNB is a selective small molecule inhibitor of thioredoxin reductase (TrxR), inhibits TrxR activity with IC50 of 9.4 uM in raw macrophages.
CDNB causes apoptosis without depletion of glutathione or loss of mitochondrial complex I-activity in neuronal cell lines.
CDNB displays an early increase of reactive oxygen species and rapid activation of stress inducible protein kinases c-Jun N-terminal kinase (JNK) and mitogen activated protein kinase kinase 4 (MKK4).
CDNB induces reactive oxygen species and subsequent activation of stress-inducible kinases without impairment of the cellular antioxidant status or mitochondrial function.
Physicochemical Properties
|
M.Wt
|
202.55
|
|
Formula
|
C6H3ClN2O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
1-chloro-2,4-dinitrobenzene
|
References
1. Heiss E, et al. Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1601-11.
2. Kang HJ, et al. Mol Cells. 2006 Aug 31;22(1):113-8.
3. Seyfried J, et al. Biochem Biophys Res Commun. 2007 Aug 3;359(3):759-64.
Contact Us
sales@probechem.com
