Catalog No.: PC-23404Not For Human Use, Lab Use Only.
NAC1 inhibitor NIC3 is a specific small molecule inhibitor of oncogenic nucleus accumbens-associated protein-1 (NAC1), inhibits NAC1 homodimerization, leading to proteasomal NAC1 degradation.
NAC1 inhibitor NIC3 is a specific small molecule inhibitor of oncogenic nucleus accumbens-associated protein-1 (NAC1), inhibits NAC1 homodimerization, leading to proteasomal NAC1 degradation. NIC3 binds to the conserved Leu-90 of NAC1 and prevents its homodimerization. NIC3 accelerates the proteasomal degradation of NAC1 protein. NIC3 significantly sensitizes drug-resistant tumor cells to cisplatin and Adriamycin in vitro and in vivo. NIC3 significantly strengthens the therapeutic efficacy of bevacizumab in a metastatic breast cancer mouse model. NIC3 is able to sensitize mice-bearing NAC1-expressing ovarian tumors to anti-PD-1 therapy.
