MASTL-IN-1 | MASTL inhibitor | Probechem Biochemicals

Chemical Structure : MASTL-IN-1

MASTL-IN-1 (MASTL inhibitor)

Catalog No.: PC-23352Not For Human Use, Lab Use Only.

MASTL-IN-1 is a potent, selective inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall) with Ki of 4.4 nM, cellular pENSA IC50 of 23 nM.

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Biological Activity

MASTL-IN-1 is a potent, selective inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall) with Ki of 4.4 nM, cellular pENSA IC50 of 23 nM.

Physicochemical Properties

M.Wt	430.51
Formula	C24H26N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9-methoxy-8-((1-methylpiperidin-4-yl)methoxy)-2-(pyrazin-2-yl)benzo[c][2,7]naphthyridin-4-amine

References

1. Gallego RA, et al. J Med Chem. 2024 Nov 5. doi: 10.1021/acs.jmedchem.4c01659.

2. Patent WO2008109613.

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