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OGT 2115

Chemical Structure : OGT 2115

CAS No.: 853929-59-6

OGT 2115 (OGT2115, OGT-2115)

Catalog No.: PC-23394Not For Human Use, Lab Use Only.

OGT 2115 is a potent, specific, cell-permeable and orally active heparanase inhibitor with IC50 of 0.4 uM, inhibits the expression and activity of heparanase.

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Biological Activity

OGT 2115 is a potent, specific, cell-permeable and orally active heparanase inhibitor with IC50 of 0.4 uM, inhibits the expression and activity of heparanase.
OGT 2115 decreases mitochondrial oxygen consumption, inhibited mitochondrial complex II-III activity.
OGT 2115 dramatically reduces HSV-2 release from vaginal epithelial cells.
OGT 2115 inhibits invasion and migration of breast cancer cells through the downregulation of heparanase.

Physicochemical Properties

M.Wt 495.30
Formula C24H16BrFN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2-(4-(3-(4-Bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid

References

1. Courtney SM, et al. Bioorg Med Chem Lett. 2005 May 2;15(9):2295-9.

2. Li Y, et al. Int J Mol Med. 2013 May;31(5):1234-42.

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