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HPA-12

Chemical Structure : HPA-12

CAS No.: 383418-30-2

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HPA-12 (HPA12)

Catalog No.: PC-23326Not For Human Use, Lab Use Only.

HPA-12 is a small molecule inhibitor of ceramide trafficking/ceramide transporter (CERT), inhibits sphingomyelin biosynthesis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HPA-12 is a small molecule inhibitor of ceramide trafficking/ceramide transporter (CERT), inhibits sphingomyelin biosynthesis.
HPA-12 inhibits conversion of ceramide to SM, but not to glucosylceramide, in Chinese hamster ovary cells.
HPA-12 does not inhibit the activity of sphingomyelin (SM) synthase.

Physicochemical Properties

M.Wt 363.54
Formula C22H37NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide

References

1. Charruyer A, et al. J Biol Chem. 2008 Jun 13;283(24):16682-92.

2. Nakamura Y, et al. J Med Chem. 2003 Aug 14;46(17):3688-95.

3. Yasuda S, et al. J Biol Chem. 2001 Nov 23;276(47):43994-4002.

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