Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-OV329
OV329

Chemical Structure : OV329

CAS No.:

OV329 (OV 329)

Catalog No.: PC-49815Not For Human Use, Lab Use Only.

OV329 (OV 329) is a highly potent inactivator of gamma-aminobutyric acid aminotransferase (GABA-AT) with Ki of 9.69 uM.

Packing Price Stock Quantity
100 mg Get quote
250 mg Get quote
500 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OV329 (OV 329) is a highly potent inactivator of gamma-aminobutyric acid aminotransferase (GABA-AT) with Ki of 9.69 uM.
OV329 is 10 times more potent as an inactivator of GABA-AT than CPP-115, OV329 has favorable pharmacokinetic properties and low off-target activities.
OV329 (5-40 mg/kg, i.p.) dose-dependently increases the thresholds of intravenous pentylenetetrazole (ivPTZ)-induced seizures.
OV329 is dramatically superior to CPP-115 in suppressing the release of dopamine in the corpus striatum, which occurs subsequent to either an acute cocaine or nicotine challenge in vivo.
OV329 also attenuates increased metabolic demands (neuronal glucose metabolism) in the hippocampus, a brain region that encodes spatial information concerning the environment in which an animal receives a reinforcing or aversive drug.

Physicochemical Properties

M.Wt 175.13
Formula C7H7F2NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3-amino-4-(difluoromethylene)cyclopent-1-ene-1-carboxylic acid

References

1. Moschitto MJ, et al. Org Lett. 2018 Aug 3;20(15):4589-4592.

2. Feja M, et al. Epilepsia. 2021 Dec;62(12):3091-3104.

3. Juncosa JI, et al. J Am Chem Soc. 2018. February 14;140:2151–2164.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: