Catalog No.: PC-49858Not For Human Use, Lab Use Only.
Tafamidis is a potent and selective transthyretin (TTR) kinetic stabilizer with EC50 of 2.7-3.2 uM for WT-TTR and mutant tetramers V30M-TTR, V122I-TTR, inhibits amyloidogenesis.
Tafamidis is a potent and selective transthyretin (TTR) kinetic stabilizer with EC50 of 2.7-3.2 uM for WT-TTR and mutant tetramers V30M-TTR, V122I-TTR, inhibits amyloidogenesis.
Tafamidis (7.2 μM) also strongly stabilized TTR heterotetramers containing WT and mutant subunits in plasma samples from patients carrying V30M or V122I mutations in plasma from patients.
Tafamidis significantly reduced the disappearance of TTR tetramer by kinetic stabilization.
