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Tafamidis

Chemical Structure : Tafamidis

CAS No.: 594839-88-0

Tafamidis

Catalog No.: PC-49858Not For Human Use, Lab Use Only.

Tafamidis is a potent and selective transthyretin (TTR) kinetic stabilizer with EC50 of 2.7-3.2 uM for WT-TTR and mutant tetramers V30M-TTR, V122I-TTR, inhibits amyloidogenesis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tafamidis is a potent and selective transthyretin (TTR) kinetic stabilizer with EC50 of 2.7-3.2 uM for WT-TTR and mutant tetramers V30M-TTR, V122I-TTR, inhibits amyloidogenesis.
Tafamidis (7.2 μM) also strongly stabilized TTR heterotetramers containing WT and mutant subunits in plasma samples from patients carrying V30M or V122I mutations in plasma from patients.
Tafamidis significantly reduced the disappearance of TTR tetramer by kinetic stabilization.

Physicochemical Properties

M.Wt 308.11
Formula C14H7Cl2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid

References

1. Bulawa CE, et al. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9629-34.

2. Lozeron P, et al. Eur J Neurol. 2013 Dec;20(12):1539-45.

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