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Chemical Structure : VSW1198
Catalog No.: PC-49016Not For Human Use, Lab Use Only.
VSW1198 is a potent, selective geranylgeranyl diphosphate synthase (GGDPS) inhibitor with IC50 of 45 nM, VSW1198 is highly specific for GGDPS over other enzymes in the isoprenoid biosynthesis (IBP) pathway.
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VSW1198 is a potent, selective geranylgeranyl diphosphate synthase (GGDPS) inhibitor with IC50 of 45 nM, VSW1198 is highly specific for GGDPS over other enzymes in the isoprenoid biosynthesis (IBP) pathway.
VSW1198 is a 3:1 mixture of E- and Z-olefin isomers, potently disrupts protein geranylgeranylation in cells at concentrations as low as 50 nM and induces cytotoxic effects at submicromolar concentrations (EC50=0.19 uM, RPMI-8226 cells).
VSW1198 disrupts Rab geranylgeranylation, leading to inhibition of monoclonal protein trafficking, induction of the unfolded protein response pathway (UPR), and apoptosis in multiple myeloma (MM) cells.
| M.Wt | 495.271 | |
| Formula | C15H23N3Na4O6P2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Haney SL, et al. Invest New Drugs. 2018 Oct;36(5):810-818.
2. Wills VS, et al. ACS Med Chem Lett. 2015;6(12):1195–1198.
3. Haney SL, et al. J Pharmacol Exp Ther. 2019 Nov;371(2):327-338.
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