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MS-L6

Chemical Structure : MS-L6

CAS No.: 63498-32-8

MS-L6

Catalog No.: PC-22285Not For Human Use, Lab Use Only.

MS-L6 is a novel small molecule OXPHOS inhibitor, exerts dual mitochondrial effects: mitochondrial electron transport chain complexe ETC-I inhibition and uncoupling of OXPHOS.

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10 mg $88 In stock
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50 mg $248 In stock
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Biological Activity

MS-L6 is a novel small molecule OXPHOS inhibitor, exerts dual mitochondrial effects: mitochondrial electron transport chain complexe ETC-I inhibition and uncoupling of OXPHOS.
MS-L6 inhibits respiration of hepatocytes and cancer cells via ETC-I.
MS-L6 decreases ΔΨm in rat liver mitochondria and cancer cells.
MS-L6 exhibits mild cytotoxic effects on several cancer cell lines and remarkably inhibits tumor growth in preclinical mouse cancer models without toxicity.

Physicochemical Properties

M.Wt 548.40
Formula C20H28Br2N4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Carbamimidothioic acid, phenyl-, 1,6-hexanediyl ester, dihydrobromide

References

1. Al Assi A, et al. Cell Death Dis. 2024 May 2;15(5):311.

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