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MS-L6

Chemical Structure : MS-L6

CAS No.: 106936-74-7

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MS-L6

Catalog No.: PC-22285Not For Human Use, Lab Use Only.

MS-L6 is a novel small molecule OXPHOS inhibitor, exerts dual mitochondrial effects: mitochondrial electron transport chain complexe ETC-I inhibition and uncoupling of OXPHOS.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MS-L6 is a novel small molecule OXPHOS inhibitor, exerts dual mitochondrial effects: mitochondrial electron transport chain complexe ETC-I inhibition and uncoupling of OXPHOS.
MS-L6 inhibits respiration of hepatocytes and cancer cells via ETC-I.
MS-L6 decreases ΔΨm in rat liver mitochondria and cancer cells.
MS-L6 exhibits mild cytotoxic effects on several cancer cell lines and remarkably inhibits tumor growth in preclinical mouse cancer models without toxicity.

Physicochemical Properties

M.Wt 386.58
Formula C20H26N4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(((Z)-N'-phenylcarbamimidoyl)thio)hexyl (E)-N'-phenylcarbamimidothioate

References

1. Al Assi A, et al. Cell Death Dis. 2024 May 2;15(5):311.

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