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Furin-IN-1d

Chemical Structure : Furin-IN-1d

CAS No.: 922732-49-8

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Furin-IN-1d (Furin inhibitor 1d)

Catalog No.: PC-70257Not For Human Use, Lab Use Only.

Furin-IN-1d is a small molecule furin inhibitor with Ki of 22 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Furin-IN-1d is a small molecule furin inhibitor with Ki of 22 nM.
    Furin-IN-1d shows comparable potency against furin and PC6B (Ki=22 nM), displays >10-fold selectivity over furin-related human PCs, such as PC7, LF and PACE4, and no activity on trypsin.
    Furin-IN-1d strongly inhibits PA processing with EC50 values of 4.2 uM, shows no significant cytotoxicity to the cells at concentrations up to 250 uM.

    Physicochemical Properties

    M.Wt 561.655
    Formula C26H35N13O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,1'-((1R,3S,4S,6R)-4-(2-amino-4-guanidinophenoxy)-6-((4-guanidinonaphthalen-1-yl)oxy)cyclohexane-1,3-diyl)diguanidine

    References

    1. Jiao GS, et al. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19707-12.

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