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NSC 306711

Chemical Structure : NSC 306711

CAS No.: 813419-93-1

NSC 306711 (Ferristatin;NSC306711)

Catalog No.: PC-61207Not For Human Use, Lab Use Only.

NSC 306711 (Ferristatin, NSC306711) is a small-molecule iron transport inhibitor that promotes degradation of the transferrin receptor independent of clathrin and dynamin, is sensitive to the cholesterol-depleting agents filipin and nystatin.

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Biological Activity

NSC 306711 (Ferristatin, NSC306711) is a small-molecule iron transport inhibitor that promotes degradation of the transferrin receptor independent of clathrin and dynamin, is sensitive to the cholesterol-depleting agents filipin and nystatin.

Physicochemical Properties

M.Wt 938.86
Formula C32H25Cu2N7O13S3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(6E)-4-Amino-6-{(2Z)-[4-(3-hydroxy-4-{2-[5-methyl-3-oxo-2-(4-sulfophenyl)-2,3-dihydro-1H-pyrazol-4-yl]hydrazino}phenyl)-6-oxo-2,4-cyclohexadien-1-ylidene]hydrazono}-5-oxo-5,6-dihydro-1,3-naphthalenedi sulfonic acid - copper (1:2)

References

1. Horonchik L, et al. Chem Biol. 2008 Jul 21;15(7):647-53.

2. Lane DJ, et al. Biochem J. 2010 Nov 15;432(1):123-32.

3. Byrne SL, et al. PLoS One. 2013 Jul 23;8(7):e70199.

4. Alkhateeb AA, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 15;308(12):G1019-26.

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