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Shz-1

Chemical Structure : Shz-1

CAS No.: 326886-05-9

Shz-1 (Shz1)

Catalog No.: PC-70268Not For Human Use, Lab Use Only.

Shz-1 is a small cardiogenic molecule that potently induces Nkx2.5 and a subset of other cardiac markers, including myocardin, troponin-I, and sarcomeric α-tropomyosin (SαTM) in a variety of different stem/progenitor cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Shz-1 is a small cardiogenic molecule that potently induces Nkx2.5 and a subset of other cardiac markers, including myocardin, troponin-I, and sarcomeric α-tropomyosin (SαTM) in a variety of different stem/progenitor cells.
Shz-1 triggers cardiac mRNA and protein expression in a variety of embryonic and adult stem/progenitor cells, including human mobilized peripheral blood mononuclear cells (M-PBMCs).
Shz-1 displays cardioregenerative activity as xenografts in injured immunocompromised rat heart.

Physicochemical Properties

M.Wt 355.21
Formula C13H11BrN2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzenesulfonic acid, [(5-bromo-2-hydroxyphenyl)methylene]hydrazide (9CI)

References

1. Sadek H, et al. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6063-8.

2. Nan C, et al. Cardiovasc Toxicol. 2015 Jan;15(1):29-40.

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