L-Propargylglycine (L-PAG) is the most commonly used, covalently irreversible inhibitor inhibitor of cystathionine γ-lyase (CSE).
L-Propargylglycine (L-PAG) is also reported to suppress the activity of other B6 enzymes, i.e. aspartate aminotransferase and alanine aminotransferase.
L-Propargylglycine (L-PAG) dose-dependently inhibits endogenous CSE activity and decreases the H2S content in Raw264.7 macrophages with IC50 of 370 uM.
Physicochemical Properties
M.Wt
113.116
Formula
C5H7NO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-2-Aminopent-4-ynoic acid hydrochloride
References
1. Antonia Asimakopoulou, et al. Br J Pharmacol. 2013 Jun;169(4):922-32.
2. Collin M, et al. Br J Pharmacol. 2005 Oct;146(4):498-505.
3. Bhatia M, et al. Br J Pharmacol. 2005 May;145(2):141-4.
