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L-Propargylglycine

Chemical Structure : L-Propargylglycine

CAS No.: 198774-27-5

L-Propargylglycine (L-PAG)

Catalog No.: PC-72155Not For Human Use, Lab Use Only.

L-Propargylglycine (L-PAG) is the most commonly used, covalently irreversible inhibitor inhibitor of cystathionine γ-lyase (CSE).

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Biological Activity

L-Propargylglycine (L-PAG) is the most commonly used, covalently irreversible inhibitor inhibitor of cystathionine γ-lyase (CSE).
L-Propargylglycine (L-PAG) is also reported to suppress the activity of other B6 enzymes, i.e. aspartate aminotransferase and alanine aminotransferase.
L-Propargylglycine (L-PAG) dose-dependently inhibits endogenous CSE activity and decreases the H2S content in Raw264.7 macrophages with IC50 of 370 uM.

Physicochemical Properties

M.Wt 113.116
Formula C5H7NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-Aminopent-4-ynoic acid hydrochloride

References

1. Antonia Asimakopoulou, et al. Br J Pharmacol. 2013 Jun;169(4):922-32.

2. Collin M, et al. Br J Pharmacol. 2005 Oct;146(4):498-505.

3. Bhatia M, et al. Br J Pharmacol. 2005 May;145(2):141-4. 

4. Tamizhselvi R, et al. J Cell Mol Med. 2007 Mar-Apr;11(2):315-26.

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