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Chemical Structure : CAY10786
CAS No.: 1239987-91-7
Catalog No.: PC-72128Not For Human Use, Lab Use Only.
CAY10786 (GPR52 antagonist Comp-43) is a highly potent and specific GPR52 antagonist with IC50 of 0.63 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $278 | In stock | |
| 100 mg | Get quote |
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CAY10786 (GPR52 antagonist Comp-43) is a highly potent and specific GPR52 antagonist with IC50 of 0.63 uM.
Comp-43 showed no effects on the cAMP elevation or calcium response stimulated by other GPCRs (β2AR, GCGR, GLP-1R, CCR5, α-1D adrenergic receptor, and dopamine D2 receptor (DRD2).
Comp-43 reduces mHTT levels by targeting GPR52 and promotes survival of mouse primary striatal neurons.
Comp-43 not only reduces mHTT levels but also rescues Huntington's disease (HD)-related phenotypes in HdhQ140 mice.
| M.Wt | 242.336 | |
| Formula | C15H14OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (2.4 mg/mL) |
|
| Chemical Name/SMILES |
(2E)-5-phenyl-1-(2-thienyl)-2-penten-1-one |
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1. Hidetoshi Komatsu. J Med Chem. 2021 Jan 28;64(2):938-940.
2. Congcong Wang, et al. J Med Chem. 2021 Jan 28;64(2):941-957.
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