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TH8535

Chemical Structure : TH8535

CAS No.: 2375215-53-3

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TH8535 (TH-8535)

Catalog No.: PC-49645Not For Human Use, Lab Use Only.

TH8535 (TH-8535) is a potent, selective inhibitor of 8-oxo Guanine DNA Glycosylase 1 (OGG1) with IC50 of 0.2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TH8535 (TH-8535) is a potent, selective inhibitor of 8-oxo Guanine DNA Glycosylase 1 (OGG1) with IC50 of 0.2 uM.
    TH8535 displays high selectivity against a number of DNA glycosylases and base excision repair enzymes (IC50>100 uM).
    TH8535 caused a significant loss of viability in a number of cancer cells at μM potency, while being better tolerated in non-transformed cell lines.

    Physicochemical Properties

    M.Wt 459.34
    Formula C21H23BrN4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(3-methoxy-4-methylphenyl)piperidine-1-carboxamide

    References

    1. Olov Wallner, et al. ChemMedChem. 2023 Jan 3;18(1):e202200310.

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