Catalog No.: PC-49633Not For Human Use, Lab Use Only.
BI-3231 (BI 3231) is a potent, selective HSD17B13 (hydroxysteroid 17β-dehydrogenase 13) inhibitor with enzyme IC50 of 1 and 14 nM for human and mouse HSD17B13, respectively.
BI-3231 (BI 3231) is a potent, selective HSD17B13 (hydroxysteroid 17β-dehydrogenase 13) inhibitor with enzyme IC50 of 1 and 14 nM for human and mouse HSD17B13, respectively.
BI-3231 displays excellent selectivity versus the structurally related homolog HSD17B11 (IC50>10 uM), as well as good selectivity in a commercial SafetyScreen44 panel, Cerep.
BI-3231 is the first potent and selective chemical probe reported for HSD17B13, a potential new target for the treatment of NASH and other liver diseases.
