Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : FK3453
Catalog No.: PC-49648Not For Human Use, Lab Use Only.
FK3453 (FK 3453) is a novel inhibitor of thymic stromal lymphopoietin (TSLP) production, reduces both TSLP protein levels and mRNA levels both in vitro and in vivo.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
FK3453 (FK 3453) is a novel inhibitor of thymic stromal lymphopoietin (TSLP) production, reduces both TSLP protein levels and mRNA levels both in vitro and in vivo.
FK3453 inhibits TSLP mRNA stimulated TNF-α (100 ng/mL) or TPA (30 nM) in PAM212 cells, but not TNF-α-induced TNF-α mRNA expression.
FK3453 inhibited TPA-induced the expression of IL-33 mRNA in NHEKs, did not affect TPA-induced phosphorylation of ERK.
FK3453 (one milliliter of 2% (w/v) CMC-Na in saline including LPS (10 ng/mL) with FK3453 (0.3 mM)) inhibited TSLP production in air-pouch type models in mice.
FK3453 is a lead compound for a novel type of medicine which prevents the onset and aggravation of allergic diseases.
| M.Wt | 307.36 | |
| Formula | C17H17N5O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Segawa R, et al. J Pharmacol Sci. 2022 Aug;149(4):198-204.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
