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Chemical Structure : Gerfelin
Catalog No.: PC-62075Not For Human Use, Lab Use Only.
Gerfelin is an osteoclastogenesis inhibitor (IC50=61 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.15 uM.
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Gerfelin is an osteoclastogenesis inhibitor (IC50=61 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.15 uM.
Gerfelin shows weak inhibitory effect due to poor cell permeability compared with Methyl gerfelin.
Gerfelin also inhibits P. falciparum GLO1.
| M.Wt | 290.271 | |
| Formula | C15H14O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zenitani S, et al. J Antibiot (Tokyo). 2003 Jul;56(7):617-21.
2. Kawatani M, et al. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11691-6.
3. Urscher M, et al. Mol Microbiol. 2010 Apr;76(1):92-103.
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