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Gerfelin

Chemical Structure : Gerfelin

CAS No.: 627545-07-7

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Gerfelin (Glyoxalase I inhibitor, GLO1 inhibitor)

Catalog No.: PC-62075Not For Human Use, Lab Use Only.

Gerfelin is an osteoclastogenesis inhibitor (IC50=61 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.15 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Gerfelin is an osteoclastogenesis inhibitor (IC50=61 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.15 uM.
    Gerfelin shows weak inhibitory effect due to poor cell permeability compared with Methyl gerfelin.
    Gerfelin also inhibits P. falciparum GLO1.

    Physicochemical Properties

    M.Wt 290.271
    Formula C15H14O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoic acid

    References

    1. Zenitani S, et al. J Antibiot (Tokyo). 2003 Jul;56(7):617-21.

    2. Kawatani M, et al. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11691-6.

    3. Urscher M, et al. Mol Microbiol. 2010 Apr;76(1):92-103.

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