GGTI-2417 |CAS:501010-05-5 Probechem Biochemicals

Chemical Structure : GGTI-2417

GGTI-2417 (GGTI2417)

Catalog No.: PC-62151Not For Human Use, Lab Use Only.

GGTI-2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I.

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Biological Activity

GGTI-2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I.
GGTI 2417 exhibits potent inhibitory activity against Rap1 geranylgeranylation with IC50 of 400 nM.
GGTI 2417 increases p27 protein levels and induces accumulation in the G0/G1 phase as well as apoptotic cell death in breast cancer cells, and prevents the degradation of nuclear p27.

Physicochemical Properties

M.Wt	455.559
Formula	C24H33N5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Leucine, N-[[(2S)-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-, methyl ester (9CI)

References

1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558.

2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63.

3. Falsetti SC, et al. Mol Cell Biol. 2007 Nov;27(22):8003-14.

GGTI-2417 (GGTI2417)

Biological Activity

Physicochemical Properties

References

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