Surfen is a small molecule antagonist of heparan sulfate, binds to heparin, low molecular weight heparins, and to HS and other GAGs.
Surfen neutralizes the ability of the various heparins to activate antithrombin and inactivate Factor Xa.
Surfen blocks sulfation and degradation of GAG chains in vitro and alters cellular responses dependent on HS such as growth factor binding and activation, cell attachment, viral infection by HSV, and angiogenesis.
Surfen also can blocks C5a receptor binding and lethal factor produced by anthrax.
Physicochemical Properties
M.Wt
372.432
Formula
C21H20N6O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,3-bis(4-amino-2-methylquinolin-6-yl)urea
References
1. Schuksz M, et al. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80.
2. Lanza TJ, et al. J Med Chem. 1992 Jan 24;35(2):252-8.
