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CMA-008

Chemical Structure : CMA-008

CAS No.: 854091-96-6

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CMA-008 (CMA008)

Catalog No.: PC-62062Not For Human Use, Lab Use Only.

CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibits Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibits Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM).
    CMA-008 selectively ablates NAADP-dependent Ca2+ oscillations induced by the external gastric peptide hormone agonist cholecystokinin (CCK) in murine pancreatic acinar cells.

    Physicochemical Properties

    M.Wt 308.075
    Formula C8H9IN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-carbamoylmethyl-3-carboxy pyridinium iodide

    References

    1. Dowden J, et al. Chem Biol. 2006 Jun;13(6):659-65.

    2. Dammermann W, et al. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10678-83.

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