SpiD7

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Chemical Structure : SpiD7

Catalog No.: PC-73365Not For Human Use, Lab Use Only.

SpiD7 is a spirocyclic dimer compound that activates the unfolded protein response (UPR), selectively inhibits growth and induce apoptosis of cancer cells.

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Biological Activity

SpiD7 is a spirocyclic dimer compound that activates the unfolded protein response (UPR), selectively inhibits growth and induce apoptosis of cancer cells.
SpiD7 activates UPR in both normal and cancer cells, and selectively induces apoptosis in cancer cells.
SpiD7 inhibits growth of high-grade serous carcinoma (HGSC) cell lines, reduces clonogenic growth and survival of HGSC cells (IC50<1 uM), activates effector caspases 3/7.

Physicochemical Properties

M.Wt	526.59
Formula	C31H30N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1',1'''-(heptane-1,7-diyl)bis(4-methylene-3,4-dihydro-5H-spiro[furan-2,3'-indoline]-2',5-dione)

References

1. Kour S, et al. J Biol Chem. 2022 Apr 1:101890.

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SpiD7

Biological Activity

Physicochemical Properties

References

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