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Mito-C

Chemical Structure : Mito-C

CAS No.: 2371004-96-3

Mito-C

Catalog No.: PC-73358Not For Human Use, Lab Use Only.

Mito-C is a specific chemical compound targeting NEETs proteins, induces mitochondrial network fragmentation and represses dengue viral replication.

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    Biological Activity

    Mito-C is a specific chemical compound targeting NEETs proteins, induces mitochondrial network fragmentation and represses dengue viral replication.
    Mito-C modifies mitochondrial morphology and dynamics by stabilizing ER‐Mitochondria contact sites (ER‐MTcs).
    Mito-C is able to counteract dengue virus‐induced mitochondria network hyperfusion and to strongly reduce Dengue virus replication, but not HBV replication cycle.
    MITO‐C shows impact on NAF1 levels and subcellular localization.
    Mito‐C causes DRP1‐dependent mitochondrial fission and ER‐mitochondria contact‐sites increase.
    Mito‐C possesses in vitro anti‐viral properties specifically against viruses that enhance mitochondrial fusion as a necessary part of their replication cycle.

    Physicochemical Properties

    M.Wt 389.466
    Formula C20H23NO5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(3,4-dimethoxybenzamido)-6,6-dimethyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

    References

    1. Diana Molino, et al. EMBO Rep. 2020 Dec 3;21(12):e49019.

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