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PRG-A01

Chemical Structure : PRG-A01

CAS No.: 1848971-22-1

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PRG-A01 (Chem-036)

Catalog No.: PC-73386Not For Human Use, Lab Use Only.

PRG-A01 is a chemical inhibitor against SOD1 misfolding and aggregation, inhibits the neuronal cell death caused by mutant-SOD1 overexpression.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PRG-A01 is a chemical inhibitor against SOD1 misfolding and aggregation, inhibits the neuronal cell death caused by mutant-SOD1 overexpression.
    PRG-A01 inhibited the aggregation formed between SOD1 and TDP-43.
    PRG-A01 demonstrated therapeutic effect of PRG-A01 in vivo, ameliorated motor neuron regression, movement disorder, and prolonged life span in SOD1G93A-Tg ALS mouse model.

    Physicochemical Properties

    M.Wt 422.43
    Formula C24H22O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate

    References

    1. Tae-Gyun Woo, et al. Commun Biol. 2021 Dec 15;4(1):1397.

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