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Lipid L319

Chemical Structure : Lipid L319

CAS No.: 1351586-50-9

Lipid L319 (O-8670, L-319)

Catalog No.: PC-38046Not For Human Use, Lab Use Only.

L-319 (O-8670) is an ionizable (pKa = 6.38) and biodegradable lipid that has been used in the formation of lipid nanoparticles.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

L-319 (O-8670) is an ionizable (pKa = 6.38) and biodegradable lipid that has been used in the formation of lipid nanoparticles.
Administration of mouse factor VII-targeting siRNA in L-319-containing lipid nanoparticles induces factor VII silencing in mice.

Physicochemical Properties

M.Wt 678.052
Formula C41H75NO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((E)-non-1-en-1-yl) 17-((E)-non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate

References

1. Martin A Maier, et al. Mol Ther. 2013 Aug;21(8):1570-8.

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