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Chemical Structure : BiTud
Catalog No.: PC-21575Not For Human Use, Lab Use Only.
BiTud is a bivalent inhibitor against TDRD3 with binding Kd of 6 uM for tandem Tudor chimera, blocks the recruitment of TDRD3 by the two methylated arginines of G3BP1, suppress the phase separation of methylated G3BP1, TDRD3, and RNAs, and in turn inhibits the stress granule growth in cells.
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BiTud is a bivalent inhibitor against TDRD3 with binding Kd of 6 uM for tandem Tudor chimera, blocks the recruitment of TDRD3 by the two methylated arginines of G3BP1, suppress the phase separation of methylated G3BP1, TDRD3, and RNAs, and in turn inhibits the stress granule growth in cells.
BiTud directly disrupts the multivalent interaction between the SG hub protein G3BP1 and its ADMA readers.
BiTud exhibits inhibitory efficacy in the SG growth and sensitizes U2OS cells to arsenite treatment.
| M.Wt | 641.55 | |
| Formula | C28H38Cl2N6O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fan WW, et al. Chem Commun (Camb). 2023 Dec 21. doi: 10.1039/d3cc04654k.
2. Patent CN113943264 A.
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