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HJ445A

Chemical Structure : HJ445A

CAS No.:

HJ445A (HJ 445A)

Catalog No.: PC-21516Not For Human Use, Lab Use Only.

HJ445A is a highly potent, selective myoferlin (MYOF) inhibitor, binds to MYOF-C2D domain with KD value of 0.17 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HJ445A is a highly potent, selective myoferlin (MYOF) inhibitor, binds to MYOF-C2D domain with KD value of 0.17 uM.
HJ445A potently inhibits the proliferation of gastric cancer cells with IC50 values of 0.16 and 0.14 μM in MGC803 and MKN45, respectively.
HJ445A prevents the migration of gastric cancer cells by reversing the epithelial–mesenchymal transition (EMT) process and inhibits the colony formation of the MKN45 cells in a concentration-dependent manner.
HJ445A efficiently induces the apoptosis of gastric cancer cells with apoptosis rates at 0, 0.1, 0.2, 0.4, and 0.8 μM were 3.1, 3.4, 5.7, 50.2, and 54.0%, respectively.
HJ445A (15 and 30 mg/kg/day) exhibited antitumor efficacy in the gastric cancer xenograft model.

Physicochemical Properties

M.Wt 445.53
Formula C24H27N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-(2-2H-1,2,3-Triazolyl)butyl)-3-(3-ethyl-5-(4-methoxyphenyl)-1-1H-1,2,4-triazolyl) Benzamide

References

1. Haijun Gu, et al. Journal of Medicinal Chemistry 2023

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