Catalog No.: PC-38736Not For Human Use, Lab Use Only.
DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, inhibits pancreatic cancer cells growth in the low nanomolar range (MIA PaCa-2, GI50=11 nM).
DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, inhibits pancreatic cancer cells growth in the low nanomolar range (MIA PaCa-2, GI50=11 nM).
DX3-213B disrupts adenosine triphosphate (ATP) generation (ATP depletion IC50=11 nM), inhibits complex I function.
Oral administration of DX3-213B (10 mg/kg) resulted in significant in vivo efficacy in a pancreatic cancer syngeneic model without obvious toxicity.
