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DX3-213B

Chemical Structure : DX3-213B

CAS No.: 2749555-66-4

DX3-213B (OXPHOS inhibitor)

Catalog No.: PC-38736Not For Human Use, Lab Use Only.

DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, inhibits pancreatic cancer cells growth in the low nanomolar range (MIA PaCa-2, GI50=11 nM).

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Biological Activity

DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, inhibits pancreatic cancer cells growth in the low nanomolar range (MIA PaCa-2, GI50=11 nM).
DX3-213B disrupts adenosine triphosphate (ATP) generation (ATP depletion IC50=11 nM), inhibits complex I function.
Oral administration of DX3-213B (10 mg/kg) resulted in significant in vivo efficacy in a pancreatic cancer syngeneic model without obvious toxicity.

Physicochemical Properties

M.Wt 478.570
Formula C20H28F2N2O5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-(4,4-difluoropiperidin-1-yl)(1-((4-(isopropylsulfonyl)phenyl)sulfonyl)piperidin-3-yl)methanone

References

1. Ding Xue, et al. J Med Chem. 2022 Feb 24;65(4):3404-3419.

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